Selected Publications

2015

The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes.; Rantakari P, Auvinen K, Jäppinen N, Kapraali M, Valtonen J, Karikoski M, Gerke H, Iftakhar-E-Khuda I, Keuschnigg J, Umemoto E, Tohya K, Miyasaka M, Elima K, Jalkanen S, Salmi M. Nat Immunol. 2015 Apr 16.PMID: 25898202

Integrin endosomal signalling suppresses anoikis.; Alanko J, Mai A, Jacquemet G, Schauer K, Kaukonen R, Saari M, Goud B, Ivaska J. Nat Cell Biol. 2015 Nov:17(11):1412-21. doi: 10.1038/ncb3250.

Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis.; Weston CJ, Shepherd EL, Claridge LC, Rantakari P, Curbishley SM, Tomlinson JW, Hubscher SG, Reynolds GM, Aalto K, Anstee QM, Jalkanen S, Salmi M, Smith DJ, Day CP, Adams DH. J Clin Invest. 2015 Feb;125(2):501-20. doi: 10.1172/JCI73722.

Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα.; Wang Y, Arjonen A, Pouwels J, Ta H, Pausch P, Bange G, Engel U, Pan X, Fackler OT, Ivaska J, Grosse R. Dev Cell. 2015 Aug 24;34(4):475-83. doi: 10.1016/j.devcel.2015.06.015.

Endothelial destabilization by angiopoietin-2 via integrin β1 activation.; Hakanpaa L, Sipila T, Leppanen VM, Gautam P, Nurmi H, Jacquemet G, Eklund L, Ivaska J, Alitalo K, Saharinen P. Nat Commun. 2015 Jan 30;6:5962. doi: 10.1038/ncomms6962.

Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation.; Šolman M, Ligabue A, Blaževitš O, Jaiswal A, Zhou Y, Liang H, Lectez B, Kopra K, Guzmán C, Härmä H, Hancock JF, Aittokallio T, Abankwa D. Elife. 2015 Aug 14;4:e08905. doi: 10.7554/eLife.08905

 

2014

Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis.; Karikoski M, Marttila-Ichihara F, Elima K, Rantakari P, Hollmen MK, Kelkka T, Gerke H, Huovinen V, Irjala H, Holmdahl R, Salmi M, Jalkanen S. Clin Cancer Res. 2014 Oct 15. PMID: 25320356

Quantitative Assessment of Myocardial Perfusion in the Detection of Significant Coronary Artery Disease: Cutoff Values and Diagnostic Accuracy of Quantitative [(15)O]H2O PET Imaging.; Danad I, Uusitalo V, Kero T, Saraste A, Raijmakers PG, Lammertsma AA, Heymans MW, Kajander SA, Pietilä M, James S, Sörensen J, Knaapen P, Knuuti J. J Am Coll Cardiol. 2014 Oct 7. PMID: 25277618

Inhibition of c-Abl kinase activity renders cancer cells highly sensitive to mitoxantrone.; Alpay K, Farshchian M, Tuomela J, Sandholm J, Aittokallio K, Siljamäki E, Kallio M, Kähäri VM, Hietanen S. PLoS One. 2014 Aug 22. PMID: 25148385

Quantification of Myocardial Blood Flow in Absolute Terms Using 82Rb PET Imaging: Results of RUBY-10 Study.; Nesterov SV, Deshayes E, Sciagrà R, Settimo L, Declerck JM, Pan XB, Yoshinaga K, Katoh C, Slomka PJ, Germano G, Han C, Aalto V, Alessio AM, Ficaro EP, Lee BC, Nekolla SG, Gwet KL, deKemp RA, Klein R, Dickson J, Case JA, Bateman T, Prior JO, Knuuti JM. JACC Cardiovasc Imaging. 2014 Oct 1. PMID: 25306543

JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size, and influences fine motor coordination.; Komulainen E, Zdrojewska J, Freemantle E, Mohammad H, Kulesskaya N, Deshpande P, Marchisella F, Mysore R, Hollos P, Michelsen KA, Mågard M, Rauvala H, James P, Coffey ET. Front Cell Neurosci. 2014 Sep 12. PMID: 25309320

In vivo imaging of reactive oxygen and nitrogen species in murine colitis.; Asghar MN, Emani R, Alam C, Helenius TO, Grönroos TJ, Sareila O, Din MU, Holmdahl R, Hänninen A, Toivola DM. Inflamm Bowel Dis. 2014 Aug 20. PMID: 24983980

Adenosine Inhibits Tumor Cell Invasion via Receptor-independent Mechanisms.; Virtanen SS, Kukkonen-Macchi A, Vainio M, Elima K, Harkonen PL, Jalkanen S, Yegutkin GG. Mol Cancer Res. 2014 Jul 30. PMID: 25080434

Retinoblastoma protein (RB) interacts with E2F3 to control terminal differentiation of Sertoli cells.; Rotgers E, Rivero-Müller A, Nurmio M, Parvinen M, Guillou F, Huhtaniemi I, Kotaja N, Bourguiba-Hachemi S, Toppari J. Cell Death Dis. 2014 Jun 5. PMID: 24901045

Axial Super-resolution by Mirror-reflected Stimulated Emission Depletion Microscopy.; Deguchi T., Koho S., Näreoja T., and Hänninen PE., Optical Review, 2014.

Mental Action Simulation Synchronizes Action-Observation Circuits across Individuals.; Nummenmaa L, Smirnov D, Lahnakoski JM, Glerean E, Jääskeläinen IP, Sams M, Hari R.; J Neurosci. 2014 Jan 15;34(3):748-57. PMID: 24431433

Vertebral bone marrow glucose uptake is inversely associated with bone marrow fat in diabetic and healthy pigs: [18F]FDG-PET and MRI study.; Huovinen V, Saunavaara V, Kiviranta R, Tarkia M, Honka H, Stark C, Laine J, Linderborg K, Tuomikoski P, Badeau RM, Knuuti J, Nuutila P, Parkkola R.Bone. 2014 Jan 3;61C:33-38. PMID: 24389418

Hyperthyroidism increases brown fat metabolism in humans.; Lahesmaa M, Orava J, Schalin-Jäntti C, Soinio M, Hannukainen JC, Noponen T, Kirjavainen A, Iida H, Kudomi N, Enerbäck S, Virtanen KA, Nuutila P.J Clin Endocrinol Metab. 2014 Jan;99(1):E28-35. PMID: 24152690

PET/CT Imaging of Integrin αvβ3 Expression in Human Carotid Atherosclerosis.;Beer AJ, Pelisek J, Heider P, Saraste A, Reeps C, Metz S, Seidl S, Kessler H, Wester HJ, Eckstein HH, Schwaiger M.; JACC Cardiovasc Imaging. 2014 Jan 2. PMID: 24412187

Absolute flow or myocardial flow reserve for the detection of significant coronary artery disease?; Joutsiniemi E, Saraste A, Pietilä M, Mäki M, Kajander S, Ukkonen H, Airaksinen J, Knuuti J.Eur Heart J Cardiovasc Imaging. 2014 Jan 9. PMID: 24408930

 

2013

Protein quantification using resonance energy transfer between donor nanoparticles and acceptor quantum dots.; Härmä H, Pihlasalo S, Cywinski PJ, Mikkonen P, Hammann T, Löhmannsröben HG, Hänninen P.Anal Chem. 2013 Mar 5;85(5):2921-6. PMID: 23391291

Nonspecific particle-based method with two-photon excitation detection for sensitive protein quantification and cell counting.; Pihlasalo S, Engbert A, Martikkala E, Ylander P, Hänninen P, Härmä H.Anal Chem. 2013 Mar 5;85(5):2689-96. PMID: 23384281

Optimization of b-value distribution for biexponential diffusion-weighted MR imaging of normal prostate.; Jambor I, Merisaari H, Aronen HJ, Järvinen J, Saunavaara J, Kauko T, Borra R, Pesola M.J Magn Reson Imaging. 2013 Oct 11. PMID: 24127398

A ZO-1/α5β1-integrin complex regulates cytokinesis downstream of PKCε in NCI-H460 cells plated on fibronectin.; Hämälistö S, Pouwels J, de Franceschi N, Saari M, Ivarsson Y, Zimmermann P, Brech A, Stenmark H,Ivaska J.PLoS One. 2013 Aug 13;8(8):e70696. PMID: 23967087

Core-shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery II: application. Prabhakar N, Näreoja T, von Haartman E, Karaman DŞ, Jiang H, Koho S, Dolenko TA, Hänninen PE, Vlasov DI, Ralchenko VG, Hosomi S, Vlasov II, Sahlgren C, Rosenholm JM.Nanoscale. 2013 May 7;5(9):3713-22. PMID: 23493921

Risks and benefits of cardiac imaging: an analysis of risks related to imaging for coronary artery disease.; Knuuti J, Bengel F, Bax JJ, Kaufmann PA, Le Guludec D, Perrone Filardi P, Marcassa C, Ajmone Marsan N, Achenbach S, Kitsiou A, Flotats A, Eeckhout E, Minn H, Hesse B.Eur Heart J. 2013 Dec 29. PMID: 24375074

Longitudinal amyloid imaging in mouse brain with 11C-PIB: comparison of APP23, Tg2576, and APPswe-PS1dE9 mouse models of Alzheimer disease.; Snellman A, López-Picón FR, Rokka J, Salmona M, Forloni G, Scheinin M, Solin O, Rinne JO, Haaparanta-Solin M.J Nucl Med. 2013 Aug;54(8):1434-41. PMID: 23833271

 

2012

BioImageXD: an open, general-purpose and high-throughput image-processing platform.; Kankaanpää P, Paavolainen L, Tiitta S, Karjalainen M, Päivärinne J, Nieminen J, Marjomäki V, Heino J, White DJ.Nat Methods. 2012 Jun 28;9(7):683-9. PMID: 22743773

JNK phosphorylation of marcksl1 determines actin stability and migration in neurons and in cancer cells.; Björkblom B., Padzik A., Mohammad H., Westerlund N., Komulainen E., Hollos P., Parviainen L.,  Papageorgiou A.C., Iljin K., Kallioniemi O., Kallajoki M., Courtney M.J., Mågård M., James P., Coffey E.T., 2012. Mol Cell Biol 32:3513-26.

Nucleolar AATF regulates c-Jun-mediated apoptosis.; Ferraris SE, Isoniemi K, Torvaldson E, Anckar J, Westermarck J, Eriksson JE.  Mol Biol Cell. 2012 23: 4323-32.

Shape engineering vs organic modification of inorganic nanoparticles as a tool for enhancing cellular internalization.; Karaman DS, Desai D, Senthilkumar R, Johansson EM, Råtts N, Odén M, Eriksson JE, Sahlgren C, Toivola DM, Rosenholm JM. Nanoscale Res Lett. 2012 7:358.

 

2011

Nestin as a regulator of Cdk5 in differentiating myoblasts.; Pallari HM, Lindqvist J, Torvaldson E, Ferraris SE, He T, Sahlgren C, Eriksson JE.. Mol Biol Cell. 2011 22: 1539-49.

Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms.; Landor SK, Mutvei AP, Mamaeva V, Jin S, Busk M, Borra R, Grönroos TJ, Kronqvist P, Lendahl U, Sahlgren CM. Proc Natl Acad Sci U S A. 2011 108: 18814-9.

SHARPIN is an endogenous inhibitor of β1-integrin activation.; Rantala, JK Pouwels J, Pellinen T, Veltel S, Laasola P,  MattilaP ,  Potter CS, Duffy T, Sundberg JP, Kallioniemi O,. Askari JA., Humphries MJ, Parsons M, Salmi M, Ivaska J., Nature Cell Biology 2011 13:1315-24

Multifunctional mesoporous silica nanoparticles for combined therapeutic, diagnostic and targeted action in cancer treatment.; Rosenholm JM, Sahlgren C, Lindén M.Curr Drug Targets. 2011 Jul 1;12(8):1166-86. Review. PMID: 21443474

Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate.; Westerlund N, Zdrojewska J, Padzik A, Komulainen E, Björkblom B, Rannikko E, Tararuk T, Garcia-Frigola C, Sandholm J, Nguyen L, Kallunki T, Courtney MJ, Coffey ET: Nat. Neurosci. 2011; 14:305-313

 

2010 and earlier

miR-18, a member of Oncomir-1, targets heat shock transcription factor 2 in spermatogenesis. Björk JK, Sandqvist A, Elsing AN, Kotaja N, Sistonen L. Development. 2010 137: 3177-84.

Cancer-cell-specific induction of apoptosis using mesoporous silica nanoparticles as drug-delivery vectors.; Rosenholm JM, Peuhu E, Bate-Eya LT, Eriksson JE, Sahlgren C, Lindén M. Small. 2010 6: 1234-41.

Protein kinase Czeta regulates Cdk5/p25 signaling during myogenesis.; de Thonel A, Ferraris SE, Pallari HM, Imanishi SY, Kochin V, Hosokawa T, Hisanaga S, Sahlgren C, Eriksson JE. Mol Biol Cell. 2010 21: 1423-34.

Functional brown adipose tissue in healthy adults.; Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerbäck S, Nuutila P.N Engl J Med. 2009 Apr 9;360(15):1518-25. PMID: 19357407

Integrin trafficking regulated by Rab21 is necessary for cytokinesis.; Pellinen T, Tuomi S, Arjonen A, Wolf M, Edgren H, Meyer H, Grosse R, Kitzing T, Rantala JK, Kallioniemi O, Fässler R, Kallio M, Ivaska J. Dev Cell. 2008 15:371-85

Vimentin function in lymphocyte adhesion and transcellular migration.; Nieminen M, Henttinen T, Merinen M, Marttila-Ichihara F, Eriksson JE, Jalkanen S.Nat Cell Biol. 2006 Feb;8(2):156-62.  PMID: 16429129

Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletionfluorescence microscopy.; Hell SW, Wichmann J.Opt Lett. 1994 Jun 1;19(11):780-2. PMID: 19844443