Turku BioImaging Screening Unit
The TBI screening unit (TBI-SU) is a recently established facility offering instrument access, expertise and services. These support medium to high-throughput imaging, high-content imaging, cell-based models, assay development, bespoke analysis algorithms, phenotypic screening and a range of additional high-throughput sample preparation, perturbation and measurement options that facilitate modern biological research, drug discovery and target validation. The unit is expanding its links with TCDM, CIC and other realted facilities, it is hosted by both the Turku Centre for Biotechnology and the Institute of Biomedicine and is situated in the Pharmacity building. Our mission is to promote drug discovery and diagnostic opportunities provided by high-throughput and high-content imaging and related technologies.
Turku Cell Imaging Core
The Cell Imaging Core (CIC) at the Turku Centre for Biotechnology is a centralized facility where users receive the support and expertise needed to carry out conventional and advanced light microscopic imaging techniques. The unit has combined resources
from Åbo Akademi University and The University of Turku to provide state-of-the-art imaging and flow cytometry equipment and services that are open to all researchers. Techniques offered include widefield and fluorescence light microscopy, confocal microscopy, microinjection, laser microdissection and high content confocal microscopy. CIC also provides hands-on training, consultation on experimental design and image analysis, and workshops for advanced users. CIC has representation in the Biocentre Finland Bioimaging Coordination, maintains links with national and international imaging centres and coordinates the Nordic Imaging Network.
Turku PET Centre
Turku PET Centre offers PET expertise in drug discovery and development, clinical expertise linking pathophysiology with the disease, human PET imaging studies and animal PET imaging studies in cooperation with Turku Centre for Disease Modeling. Turku PET Centre has a partnership agreement with Turku Imanet Oy (GE Healthcare, Medical diagnostics).
Turku Center for Disease Modeling
Turku Center for Disease Modeling (TCDM) is a research infrastructure at the Institute of Biomedicine that provides expertise in disease modeling in experimental animals. TCDM offers, in cooperation with Turku PET Centre, small animal imaging services that support both academic and industrial associated non-clinical research (basic, preclinical, translational). The following techniques are applied: Optical Imaging, MRI, PET, Ultrasound imaging and X-Ray Imaging. In cooperation with the Institute of Microbiology and Pathology, TCDM offers services imaging of tissues, cellular and subcellular structures in basic histology and in immunohistochemistry from light microscopy to electron microscopy.
EM Core Facility
Laboratory of Electron Microscopy serves as core facility for nanoscopic imaging and offers transmission electron microscopy, scanning electron microscopy, atomic force microscopy, scanning tunneling microscopy, immunocytochemistry and element analysis and localization by combined x-ray spectrometry. Samples can be prepared from e.g. tissues, cells, bacteria, viruses, nanoparticles, macromolecules and different materials. Images are recorded on sheet films or as digital image files. The facility can offer full service and consultation in planning of experiments, sample processing, microscopic examination and recording of images as well as reporting the results and their interpretation.
Imaging methodologies produce vast quantities of data that must be processed, analyzed and visualized with specialized software. Turku BioImaging offers customizable solutions through in-house software development, which includes
1) BioImageXD, a versatile and large open-source software package for post-processing biomedical images, developed by the Universities of Turku and Jyväskylä, Åbo Akademi University, and other partners.
2) Flowing Software, free software for flow cytometry data analysis, developed at the Cell Imaging Core, Turku Centre for Biotechnology.
3) Asimov, a resource management software system for imaging instruments, administered by Turku BioImaging.
Other bioimaging facilities
In addition to the facilities and centers mentioned, Turku BioImaging covers bioimaging-related functionality of many other units, such as various university departments and the VTT Technical Research Centre in Turku. Imaging techniques and services offered include for instance high-resolution STED microscopy, atomic force microscopy, two-photon confocal microscopy, fluorescence correlation spectroscopy, spinning disk confocal microscopy, fluorescence lifetime imaging, automated fluorescence microscopy and imaging mass spectrometry.